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The protective effects of hemin were evaluated by examining the hemoglobin concentration Hb and the glycosylated hemoglobin HbA1c level of blood from the rats, further calculating the numbers of TUNEL positive cells in retinal ganglion cell RGC layer and diI-labeled RGCs. Retinal ganglion cells displayed greater sensitivity to apoptosis when the HO-1 level was lower. Overexpression of HO-1 by hemin induction protected retinal ganglion cells in diabetic retinopathy through anti-inflammatory, anti-apoptotic, and anti-proliferative effects. Purchase this article with an account. Jump To Corresponding author: Gezhi Xu; xugezhi Alerts User Alerts.