Oxidative stress in cancer aids and neurodegenerative diseases pdf
N-acetylcysteine and neurodegenerative diseases: Basic and clinical pharmacology | SpringerLinkTypically in aerobic metabolism, organic compounds such as nucleic acids, proteins and lipids can undergo structural damage by oxidative reactions. Various diseases such as cancer, diabetes, cardiovascular diseases and neurodegenerative clearly exemplify the chronic oxidative stress. Therefore, it is important to consider that at low and moderate ROS levels, it can, for example, act as signaling molecules that support cell proliferation and differentiation and activate survival pathways in response to stress. Correlations between oxidative stress and disease should be carefully investigated in order to understand whether oxidative stress actually increases susceptibility to a particular disease or opposite. The generation of free radicals is a continuous physiological process, fulfilling relevant biological functions. The mechanisms of generation of free radicals occur mostly in the mitochondria, cell membranes and cytoplasm. During the metabolic processes, these radicals act as mediators for the transfer of electrons in various biochemical reactions.
Oxidative Stress in Cancer, AIDS, and Neurodegenerative Diseases Oxidative Stress and Disease
Based on a conference on Oxidative Stress and Redox Regulation, held at the Pasteur Institute, Paris, this work examines fundamental, chemical, biological and medical studies of free radicals on different targets and the consequences of their reactivity. It covers the chemistry and biochemistry of free radicals, free radicals as second messengers t.
N-acetylcysteine and neurodegenerative diseases: Basic and clinical pharmacology
The Cerebellum. Increasing lines of evidence suggest a key role of oxidative stress in neurodegenerative diseases. First, this review examines the mechanisms of action of N-acetylcysteine NAC , an antioxidant and a free radical-scavenging agent that increases intracellular GSH, at the cellular level. NAC can act as a precursor for glutathione synthesis as well as a stimulator of the cytosolic enzymes involved in glutathione regeneration. The chemical properties of NAC include redox interactions particularly with other members of the group XIV elements selenium, etc. Second, NAC has been shown to protect against oxidative stress-induced neuronal death in cultured granule neurons. Recent findings on the protective effect of NAC against 4-hydroxynonenal HNE -induced toxicity in cerebellar granule neurons are summarized.
We aimed to assess whether oxidative stress is a predictor of mortality in HIV-infected patients. Cases were patients who died with available stored plasma samples collected.
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Free radicals are common outcome of normal aerobic cellular metabolism. In-built antioxidant system of body plays its decisive role in prevention of any loss due to free radicals. However, imbalanced defense mechanism of antioxidants, overproduction or incorporation of free radicals from environment to living system leads to serious penalty leading to neuro-degeneration. Neural cells suffer functional or sensory loss in neurodegenerative diseases. Apart from several other environmental or genetic factors, oxidative stress OS leading to free radical attack on neural cells contributes calamitous role to neuro-degeneration. Toxicity of free radicals contributes to proteins and DNA injury, inflammation, tissue damage and subsequent cellular apoptosis. Antioxidants are now being looked upon as persuasive therapeutic against solemn neuronal loss, as they have capability to combat by neutralizing free radicals.
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