Sanford guide to antimicrobial therapy 2014 pdf
[PDF] The Sanford Guide to Antimicrobial Therapy - Semantic ScholarSporadic studies in antimicrobial therapy have evaluated the effects of infusion rates on therapeutic and economic outcomes, and new findings may challenge the regular infusion regimen. Focusing on studies comparing the outcomes of different infusion regimens, the relevant literature was identified by searching PubMed, Web of Science, and Scopus from January 1, to March 1, The strategy of concomitantly reducing total daily dose and prolonging infusion time may cause treatment failure eg, imipenem. Prolonged infusion of voriconazole is inferior to standard infusion because of lower efficacy caused by pharmacokinetic changes. Comparable outcomes following standard infusion and continuous infusion were observed with norvancomycin and nafcillin.
Empiric Antimicrobial Therapy in Severe Sepsis and Septic Shock: Optimizing Pathogen Clearance
Euclid Avenue, Campus Box , St. Mortality and morbidity in severe sepsis and septic shock remain high despite significant advances in critical care. Efforts to improve outcome in septic conditions have focused on targeted, quantitative resuscitation strategies utilizing intravenous fluids, vasopressors, inotropes, and blood transfusions to correct disease-associated circulatory dysfunction driven by immune-mediated systemic inflammation. This review explores an alternate paradigm of septic shock in which microbial burden is identified as the key driver of mortality and progression to irreversible shock. We propose that clinical outcomes in severe sepsis and septic shock hinge upon the optimized selection, dosing, and delivery of highly potent antimicrobial therapy.
The most trusted name in the treatment of infectious disease. Designed for use at the point of care for over 50 years, Sanford Guide continues to innovate with new tools and formats. From small family practices to international health care systems, we have an antimicrobial stewarship solution that will meet your needs. From small family practices to international health care systems, we have an antimicrobial stewardship solution that will meet your needs. Content the way you want it.